Beta blockers

Uses

Hypertension, angina, migraine, tachycardia, tremor

Mechanism

Decreased heart chronotropy (slower heart rate). (Chronotropy not as bad with ISA bb)
Depressed AV node conduction
Bronchial beta 2 receptor blockade causes bronchoconstriction (not as much with selective beta 1 bb)
Vascular beta 2 receptor blockade prevents vasodilation (not as much with selective beta 1 bb)
Alpha blockade
MSA

Table from Uptodate [1]

Name	Alpha blockade	Selectivity beta 1	ISA	MSA
Pindolol	No	No	Yes	Low
Metoprolol succinate (ER)	No	Yes	No	Low
Metoprolol tartrate	No	Yes	No	Low
Atenolol	No	Yes	No	No
Bisoprolol	No	No	No	No
Carvedilol	Yes	No	No	Yes
Propranolol	No	No	No	Yes
Nadolol	No	No	No	No
Labetalol	Yes	No	Yes	Low

Adverse effects

Beta blockers have been associated with the development of antinuclear antibodies. A cross-sectional study of 1500 hypertensive patients found a prevalence of antinuclear antibodies of more than 10 percent in those receiving atenolol, labetalol, and acebutolol. However, rheumatic symptoms (generally persistent arthralgias and myalgias) are infrequent. ANA titers and symptoms resolve after the cessation of therapy. [1]

Cytoplasmic pattern from ANA Patterns

References

[1] P Podrid. Major side effects of beta blockers. Uptodate Aug 19, 2020