Tacrolimus

Calcineurin inhibitor


 

How does Medication work?

Mechanism of action is

Calcineurin inhibitor

. 



 

What is the dose of Medication?


Start at 0.5 mg BID or 1 mg. BID. Increase based on trough levels. Typically max dose would be 10 mg. BID. Typical dosing is 1-3 mg. BID. Trough level should be in AM before AM dose. Dose 12 hours apart NOT BID so 7 AM and 7 PM, 8 AM and 8 PM. Steady state is attained after about 6 half lifes so eery 3-4 days after a dosage change. 

 

Drug-drug interactions

Cyto p450%

Azoles#

Protease inhibitors (HIV drugs)#

Verapamil, cardizem#

Macrolides - Emycin, clarithromycin




 

What are the side effects of Medication?

Common side effects%

Tremor#

Azotmeia#

Hyperglycemia#

Hyperlipidemia




 

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