Infectious diseases


Testing

Microbial cell-free DNA sequencing test for infectious disease

Zoonoses

Brucellosis

Brucellosis is characterized by fever, night sweats, and arthralgias, but pneumonia is rare. Anthrax and plague can cause severe pneumonia. [2]

Coxiella burnetii

C. burnetti, the causative agent of Q fever, causes pneumonia, fevers, night sweats, myalgias, and hepatitis. [2]

Toxoplasmosis

( see Toxoplasmosis)

Toxoplasma gondii, an intracellular protozoan, is estimated to have infected one third of the world’s population. In immunocompetent hosts, the infection is typically either asymptomatic or a self-limited mononucleosis-like illness. The parasite is commonly acquired by ingesting viable organisms in food, water, or soil. Disseminated toxoplasmosis is rare as a cause of pneumonia in immunocompetent persons. Symptomatic T. gondii infections in immunocompetent patients may be associated with lymphadenopathy, myalgias, and rash. [2]

[1] Blauwkamp, Timothy A., et al. "Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease." Nature microbiology 4.4 (2019): 663-674.

[2] Rutenberg David, Zhang Yumeng,  Montoya Jose G., Sinnott John,  Contopoulos-Ioannidis Despina G. The Meat of the Matter. 2024/05/01.  New England Journal of Medicine https://doi.org/10.1056/NEJMcps2311297